| Product Name | NPAT Antibody (M-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1091-1390 mapping near the C-terminus of NPAT of mouse origin |
| Modification Notes | The nuclear protein, ataxia telangiectasia locus (NPAT), an essential downstream component of the cyclin E/Cdk2 signaling pathway, acts as a critical regulator for S-phase entry, histone gene expression and Cajal body maintenance in somatic cells. This protein was originally identified by its chromosomal location, 11q23, and its proximity to the Atm gene, which is responsible for the autosomal recessive disease ataxia telangiectasia (AT). The NPAT protein sequence is strongly conserved in eukaryotes and its expression is ubiquitous. The C-terminal half of the NPAT protein contains multiple elements required for induction of S phase, while the N-terminal half appears to be crucial for the activation of histone H4 and H2B. NPAT contains several Cdk2 phosphorylation sites, but they do not appear to affect protein function. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NPAT of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1091-1390 mapping near the C-terminus of NPAT of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1091-1390 mapping near the C-terminus of NPAT of mouse origin |
| Entrez Gene | 4863 |
|---|
| Application Notes | recommended for detection of NPAT of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
