Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing membrane and cytoplasmic staining of cells in seminiferous ducts and cytoplasmic staining of Leydig cells.Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx showing cytoplasmic staining of respiratory epithelial cells at low magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx showing cytoplasmic staining of respiratory epithelial cells at high magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Western blot analysis of ADAM23 expression in mouse brain (A) and rat brain (B) tissue extract.| Product Name | ADAM23 Antibody (H-65) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 351-415 mapping within an extracellular domain of ADAM23 of human origin |
| Modification Notes | ADAMs (a disintegrin and metalloproteinase domain), also known as MDCs (metalloproteinase, disintegrin, and cysteine-rich domain) or cellular disintegrins, are a family of proteins that are expressed in numerous different tissues. They catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAMs are membrane-anchored proteins, and there are over 30 different members in the family with many diverse functions. ADAM 23 is exclusively expressed in fetal and adult brain and may function as an integrin ligand in cells of neural origin. Adhesion of neuroblastoma and astrocytoma cells is promoted by the disentegrin-like domain of ADAM23 and is mediated by an interaction of this protein with åv∫3. A short amino acid sequence in the disintegrin loop of ADAM23 interacts with åv∫3 to mediate cell interactions that take place during both normal and pathological processes. The three characteristic histidine residues and the glutamic acid residue typical of metalloproteinases are lacking in the metalloproteinase-like domain of ADAM23. This suggests that ADAM23 may not be involved in protease-mediated events, but could exclusively serve in cell adhesion processes. In addition, evidence suggests that ADAM23 may be a tumor suppressor gene. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of ADAM23 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 351-415 mapping within an extracellular domain of ADAM23 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 351-415 mapping within an extracellular domain of ADAM23 of human origin |
| Entrez Gene | 8745 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing membrane and cytoplasmic staining of cells in seminiferous ducts and cytoplasmic staining of Leydig cells.
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx showing cytoplasmic staining of respiratory epithelial cells at low magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx showing cytoplasmic staining of respiratory epithelial cells at high magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Western blot analysis of ADAM23 expression in mouse brain (A) and rat brain (B) tissue extract.| Application Notes | recommended for detection of ADAM23 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
