| Product Name | SMG1 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 3358-3657 mapping at the C-terminus of SMG1 of human origin |
| Modification Notes | The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (ser/thr) protein kinases. SMG1, also known as ATX or LIP, is a 3,657 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one FAT domain, one FATC domain, one HEAT repeat and one PI3K domain. Expressed in a variety of tissues, including heart and skeletal muscle, SMG1 functions as a ser/thr protein kinase that uses manganese as a cofactor to catalyze the phosphorylation of target proteins. Via its catalytic activity, SMG1 plays an important role in mRNA surveillance and genotoxic stress-induced response pathways. Multiple isoforms of SMG1 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SMG1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 3358-3657 mapping at the C-terminus of SMG1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 3358-3657 mapping at the C-terminus of SMG1 of human origin |
| Entrez Gene | 23049 |
|---|
| Application Notes | recommended for detection of SMG1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
