| Modification Notes |
ANKRD21 (ankyrin repeat domain-containing protein 21), also known as A26B3, POTE or POTE21, is a 584 amino acid peripheral membrane protein that contains 6 ankyrin repeats and belongs to the POTE family. Expressed in testis, ovary and placental tissue, as well as in prostate cancer cell lines, ANKRD21 is thought to play a role in reproductive processes, such as spermatogenesis, and may be involved in tumor progression. The gene encoding ANKRD21 maps to chromosome 21, which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer's disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21). |