Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human lung tissue showing cytoplasmic staining of macropages and peumocytes cells.Application
Western blot analysis of Jagged2 expression in untreated Jurkat (A) and GM-CSF-treated Jurkat (B) whole cell lysates.Application
Western blot analysis of human recombinant Jagged2 fusion protein.| Product Name | Jagged2 Antibody (H-143) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 914-1056 mapping near the C-terminus of Jagged2 of human origin |
| Modification Notes | The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged is a membrane protein and can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis. Jagged is expressed in adult and fetal tissues, and the expression is up-regulated in cervical squamous cell carcinoma. Familial Tetralogy of Fallot, the most common form of complex congenital heart disease, is caused by a mutation in the JAG1 gene. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of Jagged2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 914-1056 mapping near the C-terminus of Jagged2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 914-1056 mapping near the C-terminus of Jagged2 of human origin |
| Entrez Gene | 3714 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human lung tissue showing cytoplasmic staining of macropages and peumocytes cells.
Application
Western blot analysis of Jagged2 expression in untreated Jurkat (A) and GM-CSF-treated Jurkat (B) whole cell lysates.
Application
Western blot analysis of human recombinant Jagged2 fusion protein.| Application Notes | recommended for detection of Jagged2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
