Application
Western blot analysis of Calcipressin-3 expression in mouse heart tissue extract.| Product Name | Calcipressin-3 Antibody (H-25) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of Calcipressin-3 of mouse and human origin by WB, IP and ELISA |
| Modification Notes | Calcipressin-3, also known as RCAN3 (Regulator of calcineurin 3), DSCR1L2 (Down syndrome candidate region 1-like protein 2) and MCIP3 (Myocyte-enriched calcineurin-interacting protein 3), is a 241 amino acid protein that potentially is involved in central nervous system development. As its name suggests, Calcipressin-3 binds to calcineurin. Overexpression of calcipressin-3 results in inhibition of calcineurin activity towards the nuclear factor of activated T-cells (NFAT) transcription factors and also downregulates NFAT-dependent cytokine gene expression in activated Jurkat T-cells. Though expressed ubiquitously at low levels, high expression of calcipressin-3 is found in kidney, heart, liver, peripheral blood lymphocytes and skeletal muscle. Calcipressin-3 also interacts with cardiac troponin I, suggesting that it may play a role in cardiac contraction events. There are two isoforms of Calcipressin-3 that are produced as a result of alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of Calcipressin-3 of mouse and human origin by WB IP and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of Calcipressin-3 of mouse and human origin by WB, IP and ELISA |
| Entrez Gene | 11123 |
|---|
Application
Western blot analysis of Calcipressin-3 expression in mouse heart tissue extract.| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
