Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing cytoplasmic staining of glandular cells.Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes in low (A) and high (B) resolution. Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Western blot analysis of UGT2B38 expression in non-transfected 293T: (A), mouse UGT2B38 transfected 293T: (B) and NIH/3T3 (C) whole cell lysates.Application
Western blot analysis of UGT2B38 expression in non-transfected: (A) and mouse UGT2B38 transfected: (B) 293T whole cell lysates.| Product Name | UGT2B Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 188-487 mapping near the C-terminus of UGT2B4 of human origin |
| Modification Notes | UDP-glucuronosyltransferase isoenzymes (UGTs) catalyze the glucuronidation of small lipophilic molecules, which regulates the bioactivity and metabolic fate of a wide range of endo- and xenobiotics (1). Glucuronidation increases the polarity of lipophilic molecules and facilitates their entry into aqueous compartments and their ultimate excretion (1). In essence, glucuronidation provides a protective function by terminating or attenuating the biological activity of its substrates (1). The UGT2B family of isoenzymes are highly expressed in liver, but are also detected in several non-hepatic tissues, including skin, breast, prostate, intestine, placenta, and lung (2-6). Therefore, the UGT2B family may preferentially modulate steroid metabolism and excretion in addition to bile acids and xenobiotics (2,4). The human UGT2B genes localize as a cluster on chromosome 4q13 (3-5,7). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of UGT2B family members and UGT2A1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 188-487 mapping near the C-terminus of UGT2B4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 188-487 mapping near the C-terminus of UGT2B4 of human origin |
| Entrez Gene | 7363 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing cytoplasmic staining of glandular cells.
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes in low (A) and high (B) resolution. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Western blot analysis of UGT2B38 expression in non-transfected 293T: (A), mouse UGT2B38 transfected 293T: (B) and NIH/3T3 (C) whole cell lysates.
Application
Western blot analysis of UGT2B38 expression in non-transfected: (A) and mouse UGT2B38 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of UGT2B family members and UGT2A1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
