| Modification Notes |
Cutaneous T cell lymphomas (CTCL) represent a group of malignancies that originate from CD4-T lymphocytes and manifest on the skin. CTCL is a general term for several neoplasms including mycosis fungoides, T cell leukemia/lymphoma and pagetoid reticulosis, all of which are very difficult to treat in the advanced stages. CTAGE5 (cutaneous T-cell lymphoma-associated antigen 5), also known as MEA11, MEA6, MGEA11 or MGEA6, is an 804 amino acid tumor associated antigen that is found in tumors of various origins, including cutaneous T cell lymphomas. CTAGE5 is expressed as multiple isoforms due to alternative splicing events. Isoform 5A is expressed only in testis at the protein level while other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. |