TFIID is a general transcription factor that initiates preinitiation complex assembly through direct interaction with the TATA promoter element. Functioning as a multisubunit complex consisting of a small TATA-binding polypeptide and other TBP-associated factors (TAFs), TFIID mediates promoter responses to various transcriptional activators and repressors. TAF II p30, also known as TAF2A, TAF2H or TAFII30, is a 218 amino acid subunit of TFIID. Localized to the nucleus, TAF II p30 plays a role in transcriptional activation and is thought to be necessary for both cell cycle progression and cellular differentiation. Human TAF II p30 can be monomethylated at Lys-189, an event that increases TAF II p30 affinity for RNA polymerase (POLR), thereby enhancing POLR-mediated transcription.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of TAF II p30 of mouse, human and canine origin by WB, IP and ELISA: