Application
Western blot analysis of calsyntenin-3 expression in mouse brain (A) and mouse prostate (B) tissue extracts.Application
Western blot analysis of calsyntenin-3 expression in WI 38 whole cell lysate.| Product Name | calsyntenin-3 Antibody (D-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an extracellular domain of calsyntenin-3 of human origin |
| Modification Notes | Members of the calsyntenin protein family localize to the post-synaptic membrane of exicitatory central nervous system (CNS) synapses. Calsyntenin-3, also known as CSTN3, alcbeta or CLSTN3, is a 956 amino acid single-pass type I membrane protein that localizes to the membrane of the endoplasmic reticulum and the Golgi apparatus. Expressed predominantly in brain and kidney, calsyntenin-3 contains two cadherin-like repeats in its N-terminal extracellular region and binds synaptic calcium with its cytoplasmic domain, which suggests that calsyntenin-3 plays a role in the modulation of calcium-mediated postsynaptic signals. Under normal physiological conditions, calsyntenin-3 is protoeolytically processed in an event in which primary zeta-cleavage generates a short C-terminal transmembrane fragment and a long extracellular N-terminal domain. The tripartite complex, which consist of calsyntenin-3, X11∫ and Amyloid A4, inhibits intracellular Amyloid A4 maturation by stabilizing Amyloid A4 metabolism and enhancing X11∫-mediated suppression of ∫-Amyl |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of calsyntenin-3 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with calsyntenin-1 or calsyntenin-2 also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an extracellular domain of calsyntenin-3 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an extracellular domain of calsyntenin-3 of human origin |
| Entrez Gene | 9746 |
|---|
Application
Western blot analysis of calsyntenin-3 expression in mouse brain (A) and mouse prostate (B) tissue extracts.
Application
Western blot analysis of calsyntenin-3 expression in WI 38 whole cell lysate.| Application Notes | recommended for detection of calsyntenin-3 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with calsyntenin-1 or calsyntenin-2 also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
