Application
Western blot analysis of BI-1 expression in human testis tissue extract.| Product Name | BI-1 Antibody (FL-237) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BI-1,TEGT,TMBIM 6 |
| Conjugation | Agarose |
| Modification | Acetylated |
| Modification Notes | BI-1 (Bax inhibitor 1), also designated testis enhanced gene transcript (TEGT), is a regulator of cell death pathways controlled by Bcl-2 and Bax. BI-1 is an integral membrane protein containing six membrane-spanning segments and is predominantly localized to intracellular membranes, similar to Bcl-2 family proteins. The human protein contains 237 amino acids. BI-1 can interact with Bcl-2 and Bcl-XL. When overexpressed in mammalian cells, BI-1 suppresses apoptosis induced by Bax, etoposide, staurosporine and growth factor deprivation. BI-1 antisense induces apoptosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCIPWB |
| WB:1:100~1:200 IP:1:20~1:100 IF:1:20~1:100 IHC:1:10~1:50 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | BI-1 TEGT TMBIM 6 |
|---|---|
| Molecular Weight(MW) | 26 kDa |
| Tissue Specificity | epitope corresponding to amino acids 1-237 representing full length BI-1 of human origin |
| Entrez Gene | 7009 |
|---|
Application
Western blot analysis of BI-1 expression in human testis tissue extract.| Application Notes | WB:1:100~1:200 IP:1:20~1:100 IF:1:20~1:100 IHC:1:10~1:50 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
