| Product Name | SCOP Antibody (H-60) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1334-1393 mapping within an internal region of SCOP of human origin |
| Modification Notes | SCOP (Suprachiasmatic nucleus circadian oscillatory protein, PHLPP, PH domain and leucine rich repeat protein phosphatase, PLEKHE1) is a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Endogenous SCOP in human embryonic kidney cell lysates produces a major protein and minor protein. SCOP negatively regulates K-Ras signaling in membrane rafts and contributes to the regulation of the Ras-MAPK signaling pathway. Recombinant SCOP can dephosphorylate the hydrophobic motif of Akt1 (ser-473) in vitro, triggering apoptosis and suppressing tumor growth. SCOP levels appear lower in certain colon cancer and glioblastoma cell lines that show elevated Akt phosphorylation. Rat tissues that express SCOP include cerebrum, cerebellum, and testis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SCOP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1334-1393 mapping within an internal region of SCOP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1334-1393 mapping within an internal region of SCOP of human origin |
| Entrez Gene | 23239 |
|---|
| Application Notes | recommended for detection of SCOP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
