| Product Name | UROD Antibody (H-53) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 81-133 mapping within an internal region of UROD of human origin |
| Modification Notes | Uroporphyrinogen decarboxylase, also known as UROD or UPD, is a 367 amino acid protein that exists as a homodimer. UROD is the fifth enzyme in the human heme biosynthetic pathway and is responsible for the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations in the UROD gene are responsible for three autosomal disorders in humans: familial porphyria cutanea tarda (f-PCT), sporadic porphyria cutanea tarda (s-PCT) and hepatoerythropoietic porphyria (HEP). F-PCT is an autosomal dominant disorder characterized by late-onset light-sensitive dermititis. High levels of uroporphyrin excretion in the urine and varying degrees of liver damage are associated with this disease. S-PCT is an idiosyncratic form of PCT that is characterized by a reduction of liver enzymes. HEP is an autosomal recessive disorder that affects infants. It is characterized by excessive excretion of acetate-substituted porphyrins and accumulation of protoporphyrin in erythrocytes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of UROD of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 81-133 mapping within an internal region of UROD of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 81-133 mapping within an internal region of UROD of human origin |
| Entrez Gene | 7389 |
|---|
| Application Notes | recommended for detection of UROD of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
