| Product Name | Relaxin Receptor 2 Antibody (H-150) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 81-230 mapping within an extracellular domain of Relaxin Receptor 2 of human origin |
| Modification Notes | G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). Relaxin Receptor 2, also known as Relaxin/insulin-like family peptide receptor 2, RXFP2, LGR8, GREAT, GPR106, INSL3R or RXFPR2, is a leucine-rich repeat G protein-coupled receptor that binds Relaxins and INSL3 (insulin-like peptide 3). Expressed in brain, muscle, uterus, kidney, thyroid, testis, bone marrow and peripheral blood cells, Relaxin Receptor 2 localizes to the cell membrane and contains ten LRR (leucine-rich) repeats and an LDL-receptor class A domain. Upon Relaxin or INSL3 binding to Relaxin Receptor 2, adenylate (A) cyclase is activated, leading to an increased intracellular concentration of cAMP. cAMP is a key intracellular regulator; it mediates the activities of numerous hormones and plays an important role in modulating cellular activity. Mutations in the gene encoding Relaxin Receptor 2 can lead to cryptorchidism (impaired testicular descent), a condition associated with a higher risk of infertility and testicular cancer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Relaxin Receptor 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 81-230 mapping within an extracellular domain of Relaxin Receptor 2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 81-230 mapping within an extracellular domain of Relaxin Receptor 2 of human origin |
| Entrez Gene | 122042 |
|---|
| Application Notes | recommended for detection of Relaxin Receptor 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
