Application
Western blot analysis of Vitrin expression in non-transfected: (A) and mouse Vitrin transfected: (B) 293T whole cell lysates.| Product Name | Vitrin Antibody (G-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the N-terminus of Vitrin of human origin |
| Modification Notes | Vitrin (VIT) is a 678 amino acid secreted protein that exists as four alternatively spliced isoforms, and contains two VWFA domains and one LCCL domain. While it binds dermatan sulfate and chondroitin sulfate, Vitrin promotes matrix assembly and cell adhesiveness. The gene that encodes Vitrin consists of more than 118,000 bases and maps to human chromosome 2p22.2. Consisting of 237 million bases, chromosome 2 encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alström syndrome, is due to mutations in the ALMS1 gene. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Vitrin isoforms 1-3 of mouse, rat and human origin by WB, IIP, F and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of Vitrin of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of Vitrin of human origin |
| Entrez Gene | 5212 |
|---|
Application
Western blot analysis of Vitrin expression in non-transfected: (A) and mouse Vitrin transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of Vitrin isoforms 1-3 of mouse, rat and human origin by WB, IIP, F and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
