| Product Name | NK-1R Antibody (H-83) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 325-407 mapping at the C-terminus of NK-1R of human origin |
| Modification Notes | The substance P receptor, also designated NK-1R for neurokinin 1 receptor, is a member of a class of tachykinin receptors which also includes the NK-2 receptor and the NK-3 receptor (1,2). Substance P receptors bind to tachykinin peptides, including substance P, substance K and neuromedin K. NK-1R is likely to be involved in nociceptive transmission, basal ganglia function or anxiety and depression (2). NK-1R is expressed in a high proportion of spinothalmic and spinobranchial neurons located in lamina 1 (3). NK-1R neurons in the dorsal horn of the spinal cord may play a role in chronic neuropathic and inflammatory pain (4). Ligand-induced internalization of NK-1R into early endosomes deplete the cell surface of these receptors. This internalization may be involved in a down-regulation response of a cell to substance P (5,6). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NK-1R of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 325-407 mapping at the C-terminus of NK-1R of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 325-407 mapping at the C-terminus of NK-1R of human origin |
| Entrez Gene | 6869 |
|---|
| Application Notes | recommended for detection of NK-1R of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
