| Modification Notes |
In mammalian small intestine, the proton-coupled peptide transporter (PEPT) is responsible for the absorption of small peptides arising from digestion of dietary proteins. PEPT1, a hydrogen ion/peptide co-transporter, transports dipeptides and tripeptides, but not free amino acids or peptides with more than three amino acid residues. The mechanism for this transport requires proton binding and the presence of an inside-negative membrane potential. PEPT1 is 708 amino acid protein that contains 12 putative membrane-spanning domains. PEPT1 seems to play important roles in nutritional and pharmacological therapies. The mammalian kidney expresses a proton-coupled peptide transporter, PEPT2, that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. |