| Modification Notes |
The sushi domain, which is comprised of approximately 60 amino acids and four cysteines, is present in a variety of proteins where it facilitates protein-protein interactions throughout the cell. SUSD5 (sushi domain containing 5), also known as KIAA0527, is a 629 amino acid single-pass type I membrane protein containing one link domain and one sushi (CCP/SCR) domain. The gene encoding SUSD5 maps to human chromosome three which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome three. |