Application
Western blot analysis of CCDC116 expression in Ramos (A), NAMALWA (B), NTERA-2 cl.D1 (C), HeLa (D) and LNCaP (E) whole cell lysates and mouse testis tissue extract (F).| Product Name | CCDC116 Antibody (P-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of CCDC116 of human origin |
| Modification Notes | CCDC116 (coiled-coil domain containing 116) is a 515 amino acid protein that exists as two alternatively spliced isoforms. Encoded by a gene that maps to human chromosome 22q11.21, CCDC116 is induced by curcumin (diferulolylmethane), although its role is unclear. CCDC116 is significantly affected by dietary curcumin, which may have a protective role in inflammatory bowel disease (IBD) and may reduce the relapse rate in human ulcerative colitis (UC). As the second smallest human chromosome, chromosome 22 contains over 500 genes and about 49 million bases. Phelan-McDermid syndrome, Neurofibromatosis type 2 and autism are associated with chromosome 22. A schizophrenia susceptibility locus has been identified on chromosome 22 and studies show that 22q11 deletion symptoms include a high incidence of schizophrenia. Translocation between chromosomes 9 and 22 may lead to the formation of Philadelphia Chromosome and subsequent production of a novel fusion protein known as BCR-Abl, a potent cell proliferation activator found in several types of leukemia. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CCDC116 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other CCDC family members: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of CCDC116 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of CCDC116 of human origin |
| Entrez Gene | 164592 |
|---|
Application
Western blot analysis of CCDC116 expression in Ramos (A), NAMALWA (B), NTERA-2 cl.D1 (C), HeLa (D) and LNCaP (E) whole cell lysates and mouse testis tissue extract (F).| Application Notes | recommended for detection of CCDC116 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other CCDC family members: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
