| Product Name | KIR2.1 Antibody (H-40) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 378-417 mapping within a C-terminal cytoplasmic domain of KIR2.1 of human origin |
| Modification Notes | The KIR (for inwardly rectifying potassium channel) family of potassium channels possesses a greater tendency to allow potassium to flow into the cell rather than out of it. The Kir2 subunit family includes 2.1, 2.2, 2.3 and 2.4. Unlike G-protein coupled Kir3 subunits, Kir2.1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity. Kir2.1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels. In the placenta, Kir2.1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, Kir2.1 colocalizes with Kir5.1 in the proximal tubule. Kir2.1, 2.2 and 2.3 associate with the membrane-associated guanylate kinase synapse-associated protein 97 in the cerebellum and heart. Phosphorylation of Kir2.2 by protein kinase A inhibits the associates with SAP97. Arachidonic acid increases current amplitude in Kir2.3 activity but does not affect the activity of Kir2.1, 2.2 or 2.4. Kir2.4 is abundantly expressed in the neuronal retina and is sensitive to changes in extracellular pH. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of KIR2.1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 378-417 mapping within a C-terminal cytoplasmic domain of KIR2.1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 378-417 mapping within a C-terminal cytoplasmic domain of KIR2.1 of human origin |
| Entrez Gene | 3759 |
|---|
| Application Notes | recommended for detection of KIR2.1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
