| Product Name | crp Antibody (N-13) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the N-terminus of crp of E. coli origin |
| Modification Notes | Escherichia coli contains more than 250 known promoters that must be activated prior to transcription. cAMP receptor protein (crp), also known as cAMP regulatory protein and catabolite gene activator, is a 210 amino acid E. coli protein that forms a complex with cyclic AMP and binds to specific DNA sites near the promoter, resulting in homodimeric transcription activation of more than a hundred E. coli promoters. Acting as a negative regulator against its own synthesis, crp regulates transcription of several catabolite-sensitive operons. Crp activates transcription by making multiple interactions with RNA polymerase. Containing one cyclic nucleotide binding domain and one HTH crp-type DNA binding domain, crp binds DNA as a dimer to induce a severe bend in the DNA. This formation is a regulatory mechanism of crp gene expression that plays a major role in determining the molecular mechanism in gene transcription. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of crp of E. coli origin by WB, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of crp of E. coli origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of crp of E. coli origin |
| Application Notes | recommended for detection of crp of E. coli origin by WB, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
