Application
Western blot analysis of DGUOK expression in KNRK (A), NRK (B) and NIH/3T3 (C) whole cell lysates.| Product Name | DGUOK Antibody (M-108) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 170-277 mapping at the C-terminus of DGUOK of mouse origin |
| Modification Notes | DGUOK (deoxyguanosine kinase), also known as DGK, is a 277 amino acid protein that localizes to mitochondria and exists as multiple alternatively spliced isoforms. Functioning as a homodimer and highly expressed in a variety of tissues, including liver, muscle and brain, DGUOK uses ATP to catalyze the conversion of deoxyguanosine to dGMP. Via its catalytic activity, DGUOK is essential for the phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix and is an important antiviral and chemotherapeutic tool. Defects in the gene encoding DGUOK are the cause of hepatocerebral mitochondrial DNA depletion syndrome (MDS), a group of disorders that result in reduced mtDNA (mitochondrial DNA) copy number and are characterized by liver failure and neurologic abnormalities. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of DGUOK of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 170-277 mapping at the C-terminus of DGUOK of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 170-277 mapping at the C-terminus of DGUOK of mouse origin |
| Entrez Gene | 27369 |
|---|
Application
Western blot analysis of DGUOK expression in KNRK (A), NRK (B) and NIH/3T3 (C) whole cell lysates.| Application Notes | recommended for detection of DGUOK of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
