| Product Name | Six1 Antibody (M-120) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 4-111 mapping near the N-terminus of Six1 of mouse origin |
| Modification Notes | The SIX proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. SIX2, SIX4 (AREC3) and SIX5 bind to the same DNA sequence, indicating that they may regulate the same target genes. SIX1 and SIX4 are both capable of transactivating MEF3 site containing reporter genes, such as myogenin. It has been demonstrated that alterations to homeobox-containing genes may result in cancer. SIX1 expression has been shown to be absent or low in normal adult tissues, although it is expressed in several tumor types, including breast carcinoma. SIX1 overexpression has been shown to abrogate the G2 cell cycle checkpoint . |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAGSChIP |
| recommended for detection of a broad range of Six1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 4-111 mapping near the N-terminus of Six1 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 4-111 mapping near the N-terminus of Six1 of mouse origin |
| Entrez Gene | 6495 |
|---|
| Application Notes | recommended for detection of a broad range of Six1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
