| Product Name | HEL308 Antibody (H-239) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 830-1068 mapping near the C-terminus of HEL308 of human origin |
| Conjugation | Agarose |
| Modification | Acetylated |
| Modification Notes | HEL308, a DNA repair helicase, is a member of the helicase superfamily 2 and is conserved in eukaryotes and archaea. The human HEL308 gene encodes for a single stranded, 1101 amino acid protein that acts as a DNA dependent ATPase. HEL308 is expressed in ovaries, heart, spleen, thymus, prostate, liver, kidney, and pancreas. It is highly expressed in the testis. During the early stages of DNA recombination, HEL308 plays a critical role in DNA crosslink repair following replication fork arrest. HEL308 is believed to aid in restarting DNA replication by displacing the lagging strand at the stalled replication forks.. Human HEL308 shares homology with the Hel308 locus in Mus musculus and the mus308 locus in Drosophila melanogaster. In adult mice, Hel308 is only expressed in primary spermatocytes in seminiferous tubules of testis. The mus308 gene in D. melanogaster encodes a protein with structural characteristics of both DNA polymerases and helicases. The gene product may also be involved in the repair of lesions other than crosslinks. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIPWB |
| WB:1:100~1:500 IP:1:20~1:100 IF:1:5~1:20 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 830-1068 mapping near the C-terminus of HEL308 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 830-1068 mapping near the C-terminus of HEL308 of human origin |
| Entrez Gene | 113510 |
|---|
| Application Notes | WB:1:100~1:500 IP:1:20~1:100 IF:1:5~1:20 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
