| Product Name | SIR2 Antibody (d-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 524-823 mapping at the C-terminus of SIR2 of Drosophila melanogaster origin |
| Modification Notes | Control of chromosome structure plays a role in the regulation of gene expression, recombination, DNA repair, and chromosome stability. Drosophila SIR2, a NAD(+)-dependent histone deacetylase, influences euchromatic repression and heterochromatic silencing at telomeres, rDNA, and mating-type loci mediated by the Polycomb group of proteins and by physically associating with a complex containing the E(Z) histone methyltransferase. Deacetylation by SIR2 causes rearrangement of histones into a transcriptionally repressive chromatin structure. SIR2 has also been shown to be directly involved in the calorie-restriction life-span-extending pathway in Drosophila. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SIR2 of Drosophila origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 524-823 mapping at the C-terminus of SIR2 of Drosophila melanogaster origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 524-823 mapping at the C-terminus of SIR2 of Drosophila melanogaster origin |
| Application Notes | recommended for detection of SIR2 of Drosophila origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
