| Modification Notes |
TTC28 (tetratricopeptide repeat domain 28), also known as tetratricopeptide (TPR) repeat protein 28, is a 2,481 amino acid binding protein that contains 28 TPR repeats. TTC28 encodes hypothetical proteins of unknown function in both human and chimpanzee. Encoded by a gene that maps to human chromosome 22q12.1, the gene structure of TTC28 is unascertained. As the second smallest human chromosome, chromosome 22 contains over 500 genes and about 49 million bases. Phelan-McDermid syndrome, Neurofibromatosis type 2 and autism are associated with chromosome 22. A schizophrenia susceptibility locus has been identified on chromosome 22 and studies show that 22q11 deletion symptoms include a high incidence of schizophrenia. Translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein, BCR-Abl, a potent cell proliferation activator found in several types of leukemia. |