Application
Western blot analysis of human recombinant L-type Ca++ CP γ2 fusion protein.| Product Name | L-type Ca++ CP γ2 Antibody (H-80) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 244-323 mapping at the C-terminus of L-type Ca++ CP γ2 of human origin |
| Modification Notes | Excitable cells in response to membrane depolarization are involved in a variety of Ca2+-dependent processes, including muscle contraction, hormone or neurotransmitter release and gene expression (1-3). Calcium channels are highly diverse, multimeric complexes composed of an alpha-1 subunit, an intracellular beta subunit, a disulfide linked alpha-2/delta subunit and a transmembrane gamma subunit (1,4). L-type Ca2+ currents initiate muscle contraction, endocrine secretion and gene transcription, and are regulated through second-messenger activated protein phosphorylation pathways (1). L-type calcium channels may form macromolecular signaling complexes with G protein-coupled receptors, thereby enhancing the selectivity of regulating specific targets (5). L-type calcium channels in the brain specifically express the gamma-2 subunit along with gamma-3 and -4 subunits (6). The gamma-2 subunit (also known as stargazin) is abundant in synaptic plasma membranes where it regulates synaptic targeting of AMP receptors in granule cells (6,7). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of L-type Ca++ CP γ2, and, to a lesser extent, L-type Ca++ CP γ3,γ4 and γ8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 244-323 mapping at the C-terminus of L-type Ca++ CP &gamma 2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 244-323 mapping at the C-terminus of L-type Ca++ CP γ2 of human origin |
| Entrez Gene | 10369 |
|---|
Application
Western blot analysis of human recombinant L-type Ca++ CP γ2 fusion protein.| Application Notes | recommended for detection of L-type Ca++ CP γ2, and, to a lesser extent, L-type Ca++ CP γ3,γ4 and γ8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
