Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. As a member of the Krüppel C2H2-type zinc-finger protein family, ZNF491 (zinc finger protein 491) is a 437 amino acid protein containing thirteen C2H2-type zinc fingers. Localized to the nucleus, ZNF491 is thought to be involved in transcriptional regulation. The gene encoding ZNF491 localizes to chromosome 19, which is recognized for having the greatest gene density of the human chromosomes. Chromosome 19 is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs). Key genes for eye color and hair color also map to chromosome 19.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of ZNF491 of human origin by WB, IP and ELISA: