Application
Western blot analysis of TARDBP expression in non-transfected 293T: (A), mouse TARDBP transfected 293T: (B) and Hep G2 (C) whole cell lysates.Application
Western blot analysis of TARDBP expression in 293T whole cell lysate.Application
Western blot analysis of TARDBP expression in non-transfected: (A) and human TARDBP transfected: (B) 293T whole cell lysates.Application
Western blot analysis of TARDBP expression in Jurkat whole cell lysate.Application
Immuno-peroxidase staining of formalin fixed, paraffin-embedded human liver tissue showing nuclear and cytoplasmic staining.Application
Immuno-peroxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing nuclear and cytoplasmic staining.| Product Name | TARDBP Antibody (P-24) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against TARDBP of human origin |
| Modification Notes | TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as an DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of TARDBP of mouse, rat, human and canine origin by WB, IP, IF, IHC(P) and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against TARDBP of human origin |
|---|---|
| Tissue Specificity | raised against TARDBP of human origin |
| Entrez Gene | 23435 |
|---|
Application
Western blot analysis of TARDBP expression in non-transfected 293T: (A), mouse TARDBP transfected 293T: (B) and Hep G2 (C) whole cell lysates.
Application
Western blot analysis of TARDBP expression in 293T whole cell lysate.
Application
Western blot analysis of TARDBP expression in non-transfected: (A) and human TARDBP transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of TARDBP expression in Jurkat whole cell lysate.
Application
Immuno-peroxidase staining of formalin fixed, paraffin-embedded human liver tissue showing nuclear and cytoplasmic staining.
Application
Immuno-peroxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing nuclear and cytoplasmic staining.| Application Notes | recommended for detection of TARDBP of mouse, rat, human and canine origin by WB, IP, IF, IHC(P) and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
