Application
Western blot analysis of LRP2BP expression in Jurkat whole cell lysate.| Product Name | LRP2BP Antibody (B-24) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against LRP2BP of human origin |
| Modification Notes | LRP2BP (LRP2-binding protein), also known as MegBP (megalin-binding protein), is a 347 amino acid protein that contains one TPR repeat and six Sel1-like repeats. Localized to the plasma membrane and throughout the cytoplasm, LRP2BP interacts with megalin (also known as LRP2) and, via this interaction, is thought to regulate megalin function. Specifically, LRP2BP acts as a scaffold protein that, through its TPR motifs, assists in the sequestration and/or the release of transcription factors that influence megalin’s affects on endocytosis and hormone release. LRP2BP is expressed in colon, testis, small intestine and blood leukocytes, as well as in pancreatic adenocarcinoma cells, suggesting a possible role for LRP2BP in carcinogenesis. Two isoforms of LRP2BP exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of LRP2BP of mouse, rat, human and canine origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against LRP2BP of human origin |
|---|---|
| Tissue Specificity | raised against LRP2BP of human origin |
| Entrez Gene | 55805 |
|---|
Application
Western blot analysis of LRP2BP expression in Jurkat whole cell lysate.| Application Notes | recommended for detection of LRP2BP of mouse, rat, human and canine origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
