| Modification Notes |
Melanoma-associated antigens recognized by cytotoxic T lymphocytes (CTL) have been grouped into three categories: melanocyte differentiation antigens, cancer/testis-specific antigens and mutated or aberrantly expressed antigens. Many of these antigens consist of peptides that are presented to T cells by HLA molecules; they represent potential targets for cancer immunotherapy. PASD1 (PAS domain-containing protein 1), also known as CT63 (Cancer/testis antigen 63) or OX-TES-1, is a 773 amino acid nuclear protein that contains one PAS (PER-ARNT-SIM) domain and belongs to the cancer/testis-specific antigen family. Expressed in normal testis and in diffuse large B-cell lymphoma-derived cell lines, PASD1 is thought to function as a transcription factor and may be a potential multiple myeloma-associated antigen. Two isoforms of PASD1 exist due to alternative splicing events. |