| Product Name | frizzled-3 Antibody (H-166) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 501-666 mapping at the C-terminus of frizzled-3 of human origin |
| Modification Notes | The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled as well as several secreted mammalian frizzled-related proteins (FRPs) have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The FRPs are involved in the Wnt signaling pathway by regulating the intracellular levels of ∫-catenin. Frizzled-3 (Fz-3) is a widely expressed, 666 amino acid protein, with relatively high expression in the central nervous system. Frizzled-3 has been associated with schizophrenia and has been shown to play a role in neural crest formation and hair follicle development. Two named isoforms of frizzled-3 exist as a result of alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of frizzled-3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 501-666 mapping at the C-terminus of frizzled-3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 501-666 mapping at the C-terminus of frizzled-3 of human origin |
| Entrez Gene | 7976 |
|---|
| Application Notes | recommended for detection of frizzled-3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
