| Product Name | RNF5 Antibody (H-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 131-180 mapping at the C-terminus of RNF5 of human origin |
| Modification Notes | The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF5 (ring finger protein 5), also known as RMA1, NG2, G16 or RING5, is a 180 amino acid protein that localizes to the membrane and contains one RING-type zinc finger. Expressed in a wide variety of tissues, RNF5 functions as a ubiquitin ligase that can regulate cell motility by controlling the ubiquitination of paxillin, a focal adhesion phosphoprotein that is localized to the cytoskeleton. RNF5 can target paxillin for ubiquitination, thereby altering the localization of paxillin and effecting its ability to recruit signaling molecules to focal adhesions. While overexpression of RNF5 is associated with the progression of breast cancer, lowered expression levels are observed in muscular disorders, indicating an important role for RNF5 in the regulation of cytoskeletal activity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of RNF5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 131-180 mapping at the C-terminus of RNF5 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 131-180 mapping at the C-terminus of RNF5 of human origin |
| Entrez Gene | 6048 |
|---|
| Application Notes | recommended for detection of RNF5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
