Application
Western blot analysis of JP-45 expression in rat skeletal muscle tissue extract.| Product Name | JP-45 Antibody (E-15) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of JP-45 of mouse origin |
| Modification Notes | JP-45 (junctional-face membrane protein of 45 kDa homolog), also known as JSRP1 (junctional sarcoplasmic reticulum protein 1), is a 331 amino acid sarcoplasmic and endoplasmic reticulum membrane protein. Interacting with L-type Ca++ CP α1S, L-type Ca++ CP β1B and calsequestrin, JP-45 may participate in the regulation of the L-type Ca++ CP α1S voltage-sensitive calcium channel as well as the regulation of L-type Ca++ CP α1S membrane targeting and activity. JP-45 may also have a role in the excitation and contraction coupling of muscle cells via interactions with key proteins present in the sarcoplasmic reticulum (SR). JP-45’s interaction with SR proteins make it an important component to skeletal muscle development and maintenance. The gene encoding JP-45 maps to human chromosome 19p13.3, silencing of this gene, while having no effect on postnatal development, may result in decreased muscle strength. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of JP-45 of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of JP-45 of mouse origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of JP-45 of mouse origin |
| Entrez Gene | 1 |
|---|
Application
Western blot analysis of JP-45 expression in rat skeletal muscle tissue extract.| Application Notes | recommended for detection of JP-45 of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
