| Modification Notes |
GPR63 (Probable G-protein coupled receptor 63, PSP24b) is a 419 amino acid protein encoded by the human GPR63 gene. GPR63 is an orphan receptor member of the G-protein coupled receptor 1 family. G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. Key roles for G protein-coupled receptors include control of protein maturation and cell surface delivery and providing the correct framework for interactions with both heterotrimeric G proteins and arrestins to allow signal generation and its termination. GPR63 is expressed in brain tissue, most notably frontal cortex, with lower levels in the thalamus, caudate, hypothalamus and midbrain. |