Application
Western blot analysis of PTP IA-2 expression in IMR-32 (A) and MIA PaCa-2 (B) whole cell lysates.| Product Name | PTP IA-2 Antibody (H-41) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 723-763 mapping within an internal region of PTP IA-2 of human origin |
| Modification Notes | Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPå, PTP∫, PTP©, PTP∂, PTPe, PTPΩ, PTP˚ and PTPµ. Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues. PTP IA-2 (PTP insulinoma-associated protein 2), also known as PTPRN, IA2, ICA512 (islet cell antigen 512) or RPTPN, is a receptor-type PTP-like protein containing a transmembrane region, an intracellular PTP-like domain, and an extracellular N-terminus. Localizing to secretory granules, PTP IA-2 is exclusively expressed in neuroendocrine cells (including pancreatic islet cells) and is believed to participate in the regulation of secretory granule exocytosis. PTP IA-2 is an autoantigen and contributes to insulin-dependent diabetes mellitus (IDDM). The detection of autoantibodies against PTP IA-2 is commonly used as a diabetes diagnosis marker. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PTP IA-2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 723-763 mapping within an internal region of PTP IA-2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 723-763 mapping within an internal region of PTP IA-2 of human origin |
| Entrez Gene | 5798 |
|---|
Application
Western blot analysis of PTP IA-2 expression in IMR-32 (A) and MIA PaCa-2 (B) whole cell lysates.| Application Notes | recommended for detection of PTP IA-2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
