Application
Western blot analysis of IFT88 expression in non-transfected: (A) and mouse IFT88 transfected: (B) 293T whole cell lysates.| Product Name | IFT88 Antibody (N-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the N-terminus of IFT88 of human origin |
| Modification Notes | The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. IFT88 (Intraflagellar transport protein 88), also known as TG737 or TTC10 (TPR repeat protein 10), is an 833 amino acid protein that contains 12 TPR repeats and belongs to the TPR family. Expressed in lung, heart, liver, brain, pancreas, kidney and skeletal muscle, IFT88 is thought to interact with other intraflagellar transport proteins and may play a role in the assembly and maintenance of the vertebrate outer segment. Additionally, IFT88 is thought to function as a centrosomal protein that may regulate the G1 to S phase cell cycle transition in non-ciliated cells. Defects in the gene encoding IFT88 may be associated with the pathogenesis of polycystic kidney disease, a genetic disorder that is characterized by the presence of cysts within the kidneys. IFT88 expression is downregulated in hepatocellular carcinomas, suggesting a role for IFT88 in tumor suppression. Multiple isoforms of IFT88 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of IFT88 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other IFT family members also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the N-terminus of IFT88 of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the N-terminus of IFT88 of human origin |
| Entrez Gene | 8100 |
|---|
Application
Western blot analysis of IFT88 expression in non-transfected: (A) and mouse IFT88 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of IFT88 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other IFT family members also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
