| Modification Notes |
BRINP2 (BMP/retinoic acid-inducible neural-specific protein 2), also known as protein FAM5B or DBCCR1L2 (DBCCR1-like protein 2), is a 783 amino acid secreted protein that belongs to the FAM5 family. Existing as two alternatively spliced isoforms, BRINP2 is encoded by a gene that maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. |