| Product Name | RIC-3 Antibody (H-282) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 88-369 mapping at the C-terminus of RIC-3 of human origin |
| Modification Notes | RIC-3 (resistant to inhibitors of cholinesterase-3) is the mammalian homolog of the ric-3 protein from C.elegans. It contains two transmembrane domains and a coiled coil domain. RIC-3 is expressed in neurons and localizes to the endoplasmic reticulum where it plays a role in receptor folding and subunit assembly. In particular, RIC-3 is a nicotinic acetylcholine receptor (nAChR)-associated protein and it significantly enhances the subunit assembly, proper folding, stability and surface expression of several heteromeric and homomeric nAChR subtypes as well as some 5-HT3 receptors. This suggests that RIC-3 may be an important regulator of receptor expression. Several isoforms exist for RIC-3 and they exhibit overlapping but distinct localizations. In addition, these isoforms may have various affects on receptor expression. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of RIC-3 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 88-369 mapping at the C-terminus of RIC-3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 88-369 mapping at the C-terminus of RIC-3 of human origin |
| Entrez Gene | 79608 |
|---|
| Application Notes | recommended for detection of RIC-3 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
