| Product Name | connexin 31 Antibody (H-43) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 135-177 mapping within an extracellular domain of connexin 31 of human origin |
| Modification Notes | The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane a-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31, also known as GJB3 (gap junction b-3 protein), CX31, DFNA2 or EKV, is expressed in skin, testis, placenta, cochlea and developing hindbrain and, in mice, it is also found in peripheral auditory nerves. Mutations in the gene encoding connexin 31 can result in non-syndromic sensorineural deafness autosomal dominant type 2 (DFNA2) and/or erythrokeratodermia variabilis (EVK), a condition characterized by localized or generalized hyperkeratosis and random, transient erythematous patches. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of connexin 31 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA non cross-reactive with other connexin family members also reactive with additional species, including equine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 135-177 mapping within an extracellular domain of connexin 31 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 135-177 mapping within an extracellular domain of connexin 31 of human origin |
| Entrez Gene | 2707 |
|---|
| Application Notes | recommended for detection of connexin 31 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA non cross-reactive with other connexin family members also reactive with additional species, including equine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
