| Product Name | Sialin Antibody (H-90) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 21-110 mapping near the N-terminus of Sialin of human origin |
| Modification Notes | Sialin, also designated sodium/sialic acid cotransporter or membrane glycoprotein HP59, belongs to the major facilitator superfamily and the sodium/anion cotransporter family of proteins. Sialin acts as a solute translocator for anionic substances; in lysosomes it is a free sialic acid transporter. Sialin is a multi-pass membrane protein that localizes to the lysosome and is primarily detected in fetal lung and small intestine. It is also expressed in adult placenta, kidney and pancreas, and may be detected in colon, breast and ovary tumor endothelial cells as well. Defects in the SLC17A5 gene, which encodes the Sialin protein, can cause several disorders including Salla disease, an autosomal recessive sialic acid storage disease, as well as infantile sialic acid storage disorder (ISSD), a severe form of sialic acid storage disease in which affected newborns exhibit coarse features, visceromegaly (an enlargement of the internal organs) and a failure to thrive after birth. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SIalin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 21-110 mapping near the N-terminus of Sialin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 21-110 mapping near the N-terminus of Sialin of human origin |
| Entrez Gene | 26503 |
|---|
| Application Notes | recommended for detection of SIalin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
