Application
Western blot analysis of SCLT1 expression in F9 whole cell lysate.Application
Western blot analysis of SCLT1 expression in T24 (A), SK-BR-3 (B) and SK-MEL-28 (C) whole cell lysates.Application
Western blot analysis of SCLT1 expression in rat skeletal muscle (A), mouse brain (B) and rat brain (C) tissue extracts.| Product Name | SCLT1 Antibody (E-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of SCLT1 of human origin |
| Modification Notes | SCLT1 (sodium channel and clathrin linker 1), also known as CAP1A or hCAP-1A, is a 688 amino acid cytoplasmic protein that acts as a linker between the voltage-gated sodium channel, Na+ CP type Xå, and clathrin. SCLT1 is abundantly expressed in DRG (dorsal root ganglia) neurons and colocalizes with Na+ CP type Xå. SCLT1 regulates Na+ CP type Xå channel activity by promoting channel internalization. SCLT1 exists as four alternatively spliced isoforms and is encoded by a gene located on human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SCLT1 isoform 1 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with SCLT1-2, SCLT1-3 or SCLT1-4: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of SCLT1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of SCLT1 of human origin |
| Entrez Gene | 132320 |
|---|
Application
Western blot analysis of SCLT1 expression in F9 whole cell lysate.
Application
Western blot analysis of SCLT1 expression in T24 (A), SK-BR-3 (B) and SK-MEL-28 (C) whole cell lysates.
Application
Western blot analysis of SCLT1 expression in rat skeletal muscle (A), mouse brain (B) and rat brain (C) tissue extracts.| Application Notes | recommended for detection of SCLT1 isoform 1 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with SCLT1-2, SCLT1-3 or SCLT1-4: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
