| Product Name | ClpP Antibody (FL-277) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-277 representing full length ClpP of human origin |
| Modification Notes | ATP-dependent proteases were first identified in E. coli. One of these is called ClpAP or Ti, which consists of a regulatory unit, ClpA, with chaperone characteristics and an ATPase domain, and a proteolytic subunit, ClpP. This protease is involved in ATP-dependent degradation of incorrectly folded or unfolded proteins. The mammalian ClpP protein belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. ClpP is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. The functional form of ClpP is a hollow-cored particle composed of two heptameric rings joined face-to-face forming an aqueous chamber containing the proteolytic active sites. ClpX binds substrates bearing specific classes of peptide signals, denatures these proteins, and translocates them through the central pore of ClpP for degradation. ClpP displays high expression levels in skeletal muscle, intermediate levels in heart, liver, and pancreas, and low levels in brain, placenta, lung, and kidney. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ClpP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-277 representing full length ClpP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-277 representing full length ClpP of human origin |
| Application Notes | recommended for detection of ClpP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
