Application
Western blot analysis of LGP2 expression in non-transfected (A) and human LGP2 transfected (B) DHX58 whole cell lysates.Application
Western blot analysis of LGP2 expression in mouse liver (A) and mouse thymus (B) tissue extracts.| Product Name | LGP2 Antibody (H-159) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 520-678 mapping at the C-terminus of LGP2 of human origin |
| Modification Notes | Helicases are enzymes that catalyze the separation of double stranded DNA or RNA by utilizing ATP. LGP2, also known as probable ATP-dependent RNA helicase DHX58, is a 678 amino acid protein belonging to the helicase family. LGP2 acts as a negative regulator of host innate immune defense against viruses by binding dsRNA produced during viral replication. The repressor domain of LGP2 binds to RIG-I, a signaling protein involved in host defenses against hepatitis C virus (HCV). By preventing RIG-I multimerization, LGP2 negatively regulates RIG-I-mediated signaling. Localized to the cytoplasm, LGP2 contains one helicase ATP-binding domain and one helicase C-terminal domain. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LGP2 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 520-678 mapping at the C-terminus of LGP2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 520-678 mapping at the C-terminus of LGP2 of human origin |
Application
Western blot analysis of LGP2 expression in non-transfected (A) and human LGP2 transfected (B) DHX58 whole cell lysates.
Application
Western blot analysis of LGP2 expression in mouse liver (A) and mouse thymus (B) tissue extracts.| Application Notes | recommended for detection of LGP2 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
