| Product Name | Rev-erbα Antibody (H-49) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 21-69 mapping near the N-terminus of Rev-erbα of human origin |
| Modification Notes | Orphan nuclear receptors NR1D1 and NR1D2 are more commonly designated Rev-erbå and Rev-erb∫, respectively. Rev-erbå acts as a receptor for triiodothyronine and is composed of three domains: a modulating N-terminal domain, a C-terminal steroid binding domain and a DNA-binding domain. Rev-erb∫ binds to the sequences 5'-AATGTAGGTCA-3' and 5'-ATAACTAGGTCA-3' and acts as a competitive repressor of RORå function. It interacts with NCOA5 co-activator which leads to an increase in transcription. Both Rev-erbå and Rev-erb∫ are nuclear proteins belonging to the nuclear hormone receptor family of proteins. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Rev-erbα of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 21-69 mapping near the N-terminus of Rev-erb&alpha of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 21-69 mapping near the N-terminus of Rev-erbα of human origin |
| Entrez Gene | 9572 |
|---|
| Application Notes | recommended for detection of Rev-erbα of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
