Application
Western blot analysis of Desmuslin expression in human heart (A) and mouse skeletal muscle (B) tissue extracts.| Product Name | Desmuslin Antibody (M-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 741-1040 mapping within an internal region of Desmuslin of mouse origin |
| Modification Notes | Cytoskeletal intermediate filaments constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. Intermediate filaments are composed of two-chain, å-helical, coiled-coil molecules arranged on an imperfect helical lattice. They are widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Desmuslin is a type-VI intermediate filament which may act as a mechanical support to the muscle fibers by forming a linkage between the extracellular matrix via the Z-disk and the dystrophin-associated protein complex (DAPC). The Desmuslin protein interacts with desmin as well as å-dystrobrevin and is mainly expressed in heart and skeletal muscle, but can also be detected in brain. Desmuslin contains a conserved rod domain, a short N-terminal domain and a long C-terminal domain. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Desmuslin isoforms 1 and 2 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 741-1040 mapping within an internal region of Desmuslin of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 741-1040 mapping within an internal region of Desmuslin of mouse origin |
| Entrez Gene | 233335 |
|---|
Application
Western blot analysis of Desmuslin expression in human heart (A) and mouse skeletal muscle (B) tissue extracts.| Application Notes | recommended for detection of Desmuslin isoforms 1 and 2 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
