| Product Name | PIG-U Antibody (H-45) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 4-48 mapping near the N-terminus of PIG-U of human origin |
| Modification Notes | Phosphatidylinositol-glycans (PIGs) are multi-pass transmembrane proteins that localize to the endoplasmic reticulum. PIGs are crucial for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. PIGs play a role in the recognition of either the GPI attachment signal or the lipid portion of GPI. PIG-U (CDC91L1) is a critical part of GPI transamidase (GPIT), a multisubunit membrane-bound complex also consisting of Gaa1, Gpi8, PIG-S, and PIG-T. GPIT recognizes C-terminal signal sequences on proproteins and replaces them with specific GPI lipids. The PIG-U gene is oncogenic and is implicated in the development of human bladder cancer. Overexpression of PIG-U causes increased expression of the urokinase receptor (uPAR), a GPI-anchored protein, thereby amplifying signal transducer and activator of transcription (STAT-3) phosphorylation in bladder cancer cells, which may lead to cancer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PIG-U of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 4-48 mapping near the N-terminus of PIG-U of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 4-48 mapping near the N-terminus of PIG-U of human origin |
| Entrez Gene | 128869 |
|---|
| Application Notes | recommended for detection of PIG-U of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
