| Product Name | MINK1 Antibody (H-117) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 524-640 mapping within an internal region of MINK1 of human origin |
| Modification Notes | MINK1 (misshapen-like kinase 1, mitogen-activated protein kinase kinase kinase kinase 6, GCK family kinase MINK) is a 1,332 amino acid protein en-coded by the human gene MINK1. MINK1 belongs to the protein kinase superfamily, Ste Ser/Thr protein kinase family, Ste20 subfamily and contains one CNH domain and one protein kinase domain. MINK1 acts as a serine/thre-onine kinase and may play a role in the response to environmental stress. It appears to act upstream of the Jun N-terminal pathway and may play a role in the development of the brain. MINK1 is expressed in all tissues with highest expression found in the brain. Thymocytes that engage MHC-self peptide complexes with intermediate affinity are expanded in the thymus through a process of positive selection, whereas those that bind to these complexes with high affinity are eliminated through a process of negative selection. MINK1 is thought to be an essential component of the signaling element that couples the T cell receptor for negative, but not positive, selection. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MINK1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 524-640 mapping within an internal region of MINK1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 524-640 mapping within an internal region of MINK1 of human origin |
| Entrez Gene | 50488 |
|---|
| Application Notes | recommended for detection of MINK1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
