| Product Name | TRAF7 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 291-590 mapping within an internal region of TRAF7 of human origin |
| Modification Notes | Tumor necrosis factor receptor-associated factor (TRAF) protein family members are critically involved in pathways triggered by tumor necrosis factor (TNF) receptors and Toll/interleukin-1 receptor (TIR)-containing receptors. TRAF7 contains an N-terminal RING and zinc finger domain and localizes to the cytoplasm and nucleus of cells in the M1 phase. TRAF7 activates IKKs-I˚Bå and MKK3/6-p38 pathways which stimulate Toll-like receptor 2 (TLR2) signaling. TLR2 activates innate immunity, induces development of the acquired immunity, and also leads to the harmful inflammatory responses that can occur with infectious diseases. TRAF7 has E3 ubiquitin ligase activity, and it binds to the DNA-binding domain of the oncogenic c-Myb, via the WD40 repeats, and stimulates its sumoylation. This forces c-Myb to stay in the cytosol rather than the nucleus and thereby inhibits its activity. TRAF7 also stimulates MEKK3-mediated AP1 and CHOP activation and induces apoptosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TRAF7 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 291-590 mapping within an internal region of TRAF7 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 291-590 mapping within an internal region of TRAF7 of human origin |
| Entrez Gene | 84231 |
|---|
| Application Notes | recommended for detection of TRAF7 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
