Application
Western blot analysis of XPG expression in non-transfected: (A) and human XPG transfected: (B) 293T whole cell lysates.Application
Western blot analysis of XPG expression in non-transfected: (A) and human XPG transfected: (B) 293T whole cell lysates.| Product Name | XPG Antibody (T-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of XPG of human origin |
| Modification Notes | Seven complementation groups (A-G) of xeroderma pigmentosum have been described. The xeroderma pigmentosum group A protein, XPA, is a zinc metalloprotein which preferentially binds to DNA damaged by ultraviolet (UV) radiation and chemical carcinogens. XPA is a DNA repair enzyme that has been shown to be required for the incision step of nucleotide excision repair. XPG (also designated ERCC5) is an endonuclease that makes the 3’ incision in DNA nucleotide excision repair. Mammalian XPG is similar in sequence to yeast RAD2. Conserved residues in the catalytic center of XPG are important for nuclease activity and function in nucleotide excision repair. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of XPG of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of XPG of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of XPG of human origin |
| Entrez Gene | 2073 |
|---|
Application
Western blot analysis of XPG expression in non-transfected: (A) and human XPG transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of XPG expression in non-transfected: (A) and human XPG transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of XPG of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
